Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sapropterin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAH known ✓ | P00439 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | NOS1 | P29475 | 6/20 | 0.64 |
| ▸ | CASP7 | P55210 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | NOS3 | P29474 | 2/20 | 0.51 |
| ▸ | NOS2 | P35228 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RGS12 | O14924 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sapropterin SCHEMBL423477 | 1.00 | KDM4E (0.66) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL258963 | 1.00 | KDM4E (0.66) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL1070420 | 1.00 | KDM4E (0.66) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL31673726 | 0.99 | NOS1 (0.65) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL20769839 | 0.99 | NOS1 (0.65) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL37480 | 0.99 | NOS1 (0.65) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL1534380 | 0.99 | NOS1 (0.65) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL28826011 | 0.99 | NOS1 (0.65) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL258544 | 0.99 | NOS1 (0.65) | KDM4EMAPTBLMKMT2AALDH1A1 | |
| Sapropterin SCHEMBL25915067 | 0.99 | NOS1 (0.65) | KDM4EMAPTBLMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190167598-A1 | A NOVEL TREATMENT REGIMEN INVOLVING SAPROPTERIN DIHYDROCHLORIDE | DIPHARMA S.A. (SZ) | 2019-06-06 | — | — | US | disclosed |