Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CES1 | P23141 | 3/20 | 0.55 |
| ▸ | MIF | P14174 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29537777 | 1.00 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL22625268 | 0.85 | ALDH1A1 (0.58) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL19462940 | 0.83 | ALDH1A1 (0.42) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL8479428 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL8479422 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL15959923 | 0.81 | CES1 (0.67) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL31428577 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL19463022 | 0.76 | ALDH1A1 (0.57) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL22625306 | 0.76 | MAPK1 (0.57) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT | |
| SCHEMBL15959924 | 0.75 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210053933-A1 | THERAPEUTIC AURONES | Middle Tennessee State University (US) | 2021-02-25 | — | — | US | disclosed |
| US-10899727-B2 | Therapeutic aurones | Middle Tennessee State University (US) | 2021-01-26 | — | — | US | disclosed |
| US-20200399238-A1 | THERAPEUTIC AURONES | Middle Tennessee State University (US) | 2020-12-24 | — | — | US | disclosed |
| US-20200399238-A1 | THERAPEUTIC AURONES | Middle Tennessee State University (US) | 2020-12-24 | — | — | US | disclosed |
| WO-2020223439-A1 | AURONES AND METHODS OF USING AURONES TO TREAT TUBERCULOSIS | Middle Tennessee State University (US) | 2020-11-05 | — | — | WO | disclosed |
| US-20190169151-A1 | THERAPEUTIC AURONES | Middle Tennessee State University (US) | 2019-06-06 | — | — | US | disclosed |
| US-20190169151-A1 | THERAPEUTIC AURONES | Middle Tennessee State University (US) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10899727-B2 | Therapeutic aurones | AURKA, PIGS, PRF1 | ALDH1A1 2134/4885MAPT 3325/4885SMN1; SMN2 4248/4885 |
| US-20200399238-A1 | THERAPEUTIC AURONES | AURKA, PIGS, PRF1 | ALDH1A1 2134/4885MAPT 3325/4885SMN1; SMN2 4248/4885 |
| US-20210053933-A1 | THERAPEUTIC AURONES | AURKA, PIGS, PRF1 | ALDH1A1 2134/4885MAPT 3325/4885SMN1; SMN2 4248/4885 |
| US-20190169151-A1 | THERAPEUTIC AURONES | AURKA, PIGS, PRF1 | ALDH1A1 2134/4885MAPT 3325/4885SMN1; SMN2 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.