Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21047093 | 1.00 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL21047088 | 1.00 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL19859826 | 0.80 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL19859827 | 0.80 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL19859825 | 0.80 | ALDH1A1 (0.40) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL19859550 | 0.77 | GRM4 (0.40) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL19859548 | 0.77 | GRM4 (0.40) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL19859554 | 0.77 | GRM4 (0.40) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL11618399 | 0.75 | GAA (0.49) | ALDH1A1GAAMAPTKMT2ACA1 | |
| SCHEMBL5473598 | 0.72 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTKMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | METAP2, DNPEP, FOLH1 | ALDH1A1 608/4885GAA 43/4885MAPT 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.