Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | GBA1 | P04062 | 2/20 | 0.33 |
| ▸ | UGCG | Q16739 | 2/20 | 0.33 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678974 | 1.00 | HSD11B1 (0.50) | HSD11B1CYP2C9EPHX2GBA1UGCG | |
| SCHEMBL16567928 | 1.00 | HSD11B1 (0.50) | HSD11B1CYP2C9EPHX2GBA1UGCG | |
| SCHEMBL21426648 | 0.82 | HSD11B1 (0.37) | HSD11B1CYP2C9GBA1UGCGGBA2 | |
| SCHEMBL8057669 | 0.82 | HSD11B1 (0.38) | HSD11B1CYP2C9EPHX2GBA1UGCG | |
| SCHEMBL22642716 | 0.80 | HSD11B1 (0.39) | HSD11B1CYP2C9 | |
| SCHEMBL2747594 | 0.77 | HSD11B1 (0.46) | HSD11B1CYP2C9EPHX2 | |
| SCHEMBL3318288 | 0.71 | — | — | |
| SCHEMBL13398605 | 0.71 | — | — | |
| SCHEMBL1066102 | 0.69 | — | — | |
| SCHEMBL1924918 | 0.69 | HSD11B1 (0.61) | HSD11B1CYP2C9EPHX2CXCR3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204387-B1 | TRIAZOLOPYRAZINONES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2019-06-12 | — | — | EP | disclosed |