Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048803 | 0.92 | TP53 (0.40) | HSD17B10LMNATP53HSP90AA1GAA | |
| SCHEMBL17258751 | 0.84 | KCNA5 (0.46) | LMNAKDM4AHPGDKDM4EALDH1A1 | |
| SCHEMBL5015072 | 0.80 | NPC1 (0.54) | HSD17B10LMNATP53HSP90AA1GAA | |
| SCHEMBL31705342 | 0.77 | KDM4A (0.44) | GAAKDM4AALDH1A1NQO2KCNA5 | |
| SCHEMBL13104124 | 0.77 | KDM4A (0.44) | GAAKDM4AKCNA5NPC1RAB9A | |
| SCHEMBL15171404 | 0.76 | NPC1 (0.52) | KDM4ASMN1; SMN2EPHX2KDM4EALDH1A1 | |
| SCHEMBL21048807 | 0.76 | KCNA5 (0.43) | LMNAKDM4AHPGDKDM4EALDH1A1 | |
| SCHEMBL27669339 | 0.76 | KDM4A (0.43) | HSD17B10LMNATP53HSP90AA1GAA | |
| SCHEMBL21048804 | 0.75 | JAK2 (0.41) | HSD17B10LMNATP53HSP90AA1GAA | |
| SCHEMBL21048954 | 0.75 | LMNA (0.38) | HSD17B10LMNATP53HSP90AA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |