Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048954 | 0.91 | LMNA (0.38) | JAK2JAK1TYK2JAK3HTT | |
| SCHEMBL21048852 | 0.86 | ALDH1A1 (0.42) | JAK2JAK1TYK2JAK3HTT | |
| SCHEMBL21048808 | 0.85 | TP53 (0.44) | JAK2JAK1TYK2JAK3TP53 | |
| SCHEMBL21048855 | 0.84 | JAK2 (0.44) | JAK2JAK1TYK2JAK3HTT | |
| SCHEMBL21048857 | 0.78 | HTT (0.39) | JAK2JAK1TYK2JAK3HTT | |
| SCHEMBL5015072 | 0.77 | NPC1 (0.54) | HTTTP53LMNAHSP90AA1GAA | |
| SCHEMBL17258976 | 0.76 | TP53 (0.42) | JAK2TYK2JAK3TP53KDM4A | |
| SCHEMBL21048924 | 0.75 | HSD17B10 (0.42) | HTTTP53LMNAHSP90AA1GAA | |
| SCHEMBL17258776 | 0.74 | JAK2 (0.42) | JAK2JAK1TYK2JAK3TP53 | |
| SCHEMBL31705342 | 0.74 | KDM4A (0.44) | GAAKDM4AALDH1A1NQO2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |