Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 3/20 | 0.36 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440209 | 0.94 | CENPE (0.43) | CENPEGSK3AGSK3BLMNAMEN1 | |
| SCHEMBL2103263 | 0.88 | CENPE (0.48) | CENPELMNACCR2KIFC1P2RX3 | |
| SCHEMBL2104958 | 0.86 | CENPE (0.50) | CENPEMEN1KMT2AHPGDKIFC1 | |
| SCHEMBL3469159 | 0.85 | CENPE (0.51) | CENPELMNAMEN1KMT2AHPGD | |
| SCHEMBL2101923 | 0.85 | CENPE (0.51) | CENPELMNAMEN1KMT2AHPGD | |
| SCHEMBL2106289 | 0.78 | CENPE (0.53) | CENPEMEN1KMT2AHPGDKIFC1 | |
| SCHEMBL4561631 | 0.78 | CENPE (0.49) | CENPEGSK3AGSK3BLMNAMEN1 | |
| SCHEMBL2105954 | 0.78 | CENPE (0.61) | CENPEMEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL2104926 | 0.76 | CENPE (0.56) | CENPELMNAMEN1KMT2AHPGD | |
| SCHEMBL4769873 | 0.76 | SCD (0.45) | LMNAMEN1KMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163919-B2 | Imidazopyridinyl benzamide mitotic kinesin inhibitors | CYTOKINETICS, INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |