Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469159 | 0.89 | CENPE (0.51) | SCDMAPTKDM4ESMN1; SMN2HTT | |
| SCHEMBL2101923 | 0.89 | CENPE (0.51) | SCDMAPTKDM4ESMN1; SMN2HTT | |
| SCHEMBL4774274 | 0.89 | TAS1R3 (0.44) | MAPTKDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2630562 | 0.88 | MAPT (0.47) | SCDMAPTKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL13644428 | 0.85 | TAS1R3 (0.41) | MAPTKDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10214857 | 0.85 | F10 (0.41) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL13183917 | 0.83 | TAS1R3 (0.41) | MAPTKDM4EROCK2KMT2AMEN1 | |
| SCHEMBL3233447 | 0.82 | TAS1R3 (0.44) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL4773750 | 0.82 | MAPT (0.49) | MAPTKDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4561631 | 0.81 | CENPE (0.49) | SCDMAPTKDM4ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742907-A4 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1742907-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005107762-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |