Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HRH2 | P25021 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL22362259 | 0.94 | HRH2 (0.55) | ATF4KDM4EALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL24225679 | 0.90 | ATF4 (0.57) | ATF4KDM4EALDH1A1SMN1; SMN2HRH2 | |
| Trifluoroacetic Acid SCHEMBL21819684 | 0.85 | ATF4 (0.56) | ATF4HRH3 | |
| Trifluoroacetic Acid SCHEMBL21050183 | 0.84 | ATF4 (0.47) | ATF4HRH3 | |
| SCHEMBL22373786 | 0.83 | HRH3 (0.56) | ATF4KDM4EHRH2HRH1HRH3 | |
| Trifluoroacetic Acid SCHEMBL21050137 | 0.83 | ATF4 (0.59) | ATF4 | |
| Trifluoroacetic Acid SCHEMBL21050143 | 0.82 | ATF4 (0.58) | ATF4ALDH1A1SMN1; SMN2POLBHRH3 | |
| SCHEMBL21050128 | 0.81 | ATF4 (0.61) | ATF4KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL28513178 | 0.81 | ATF4 (0.59) | ATF4KDM4EALDH1A1SMN1; SMN2HRH1 | |
| Trifluoroacetic Acid SCHEMBL21819273 | 0.80 | ATF4 (0.70) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047589-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2023-02-16 | — | — | US | disclosed |
| US-11230542-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2022-01-25 | — | — | US | disclosed |
| EP-3723762-A2 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2020-10-21 | — | — | EP | disclosed |
| CN-111757739-A | Integrated stress pathway inhibitors | 普拉西斯生物技术有限责任公司 | 2020-10-09 | — | — | CN | disclosed |
| WO-2019118785-A2 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2019-06-20 | — | — | WO | disclosed |
| US-20190177310-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230542-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | ATF4 1/4885KDM4E 4626/4885ALDH1A1 4073/4885 |
| US-20230047589-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885KDM4E 4626/4885ALDH1A1 4073/4885 |
| US-20190177310-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885KDM4E 4626/4885ALDH1A1 4073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.