Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 9/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.38 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.38 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.38 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050961 | 0.90 | KRAS (0.43) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21050970 | 0.90 | KRAS (0.43) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21050659 | 0.89 | KRAS (0.40) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21099404 | 0.85 | KRAS (0.41) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21136716 | 0.82 | KRAS (0.41) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21099285 | 0.82 | KRAS (0.41) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21050761 | 0.81 | KRAS (0.68) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21050943 | 0.80 | MAPT (0.36) | KRASALDH1A1LMNAMAPT | |
| SCHEMBL21050815 | 0.80 | KRAS (0.53) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21050746 | 0.78 | PIN1 (0.43) | KRASALDH1A1LMNAMAPTPIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597405-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2020-03-24 | — | — | US | disclosed |
| US-20190177338-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | KRAS 272/4885EGFR 568/4885HMOX2 1418/4885 |
| US-10597405-B2 | Chemical compounds | MKI67, CCNI, MCL1 | KRAS 272/4885EGFR 568/4885HMOX2 1418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.