Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 9/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | PGR | P06401 | 5/20 | 1.00 |
| ▸ | CNR1 | P21554 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | AR | P10275 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amcinonide SCHEMBL13026154 | 1.00 | HIF1A (1.00) | HIF1ALMNACYP3A4NR3C1PGR | |
| Amcinonide SCHEMBL4720 | 1.00 | HIF1A (1.00) | HIF1ALMNACYP3A4NR3C1PGR | |
| Amcinonide SCHEMBL1649481 | 1.00 | HIF1A (1.00) | HIF1ALMNACYP3A4NR3C1PGR | |
| Amcinonide SCHEMBL5488922 | 1.00 | HIF1A (1.00) | HIF1ALMNACYP3A4NR3C1PGR | |
| Amcinonide SCHEMBL12396698 | 1.00 | HIF1A (1.00) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL11422147 | 0.93 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL15975096 | 0.93 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL28971361 | 0.93 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL14884636 | 0.93 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL124165 | 0.93 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10538551-B2 | Process for preparation of corticosteroids | CORAL DRUGS PVT. LTD. (IN) | 2020-01-21 | — | — | US | claimed |
| US-20190177361-A1 | NOVEL PROCESS FOR PREPARATION OF CORTICOSTEROIDS | CORAL DRUGS PVT. LTD. (IN) | 2019-06-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10538551-B2 | Process for preparation of corticosteroids | HSD17B7, NR3C2, CYP21A2 | NR3C1 17/4885HIF1A 3248/4885LMNA 2998/4885 |
| US-20190177361-A1 | NOVEL PROCESS FOR PREPARATION OF CORTICOSTEROIDS | HSD17B7, NR3C2, CYP11B1 | NR3C1 18/4885HIF1A 3140/4885LMNA 3377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.