Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 8/20 | 0.61 |
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.61 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 2/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9048201 | 0.84 | CHRM3 (0.83) | CHRM2CHRM1CHRM3CYP2D6CHRM4 | |
| Formic Acid SCHEMBL21052204 | 0.82 | CHRM2 (0.71) | CHRM2CHRM1CHRM3CYP2D6CHRM4 | |
| SCHEMBL21087776 | 0.78 | CHRM2 (0.72) | CHRM2CHRM1CHRM3BCHEACHE | |
| Bromide SCHEMBL5006661 | 0.75 | APOBEC3A (0.51) | CHRM2CHRM1CHRM3APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL5006664 | 0.75 | APOBEC3A (0.51) | CHRM2CHRM1CHRM3APOBEC3AAPOBEC3G | |
| Iodide SCHEMBL4090662 | 0.75 | CHRM2 (0.58) | CHRM2CHRM1CHRM3CYP2D6CHRM4 | |
| SCHEMBL6231206 | 0.74 | CHRM2 (0.59) | CHRM2CHRM1CHRM3CYP2D6CHRM4 | |
| Iodide SCHEMBL4094587 | 0.72 | CHRM2 (0.55) | CHRM2CHRM1CHRM3CYP2D6CHRM4 | |
| SCHEMBL13399626 | 0.71 | CHRM2 (0.59) | CHRM2CHRM1CHRM3CYP2D6CHRM4 | |
| SCHEMBL27519034 | 0.70 | KMT2A (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720852-A1 | FLUOROPHENYL SUBSTITUTED MUSCARINIC RECEPTOR LIGANDS WITH SELECTIVITY FOR M3 OVER M2 | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2020-10-14 | — | — | EP | disclosed |
| US-20200308168-A1 | FLUOROPHENYL SUBSTITUTED MUSCARINIC RECEPTOR LIGANDS WITH SELECTIVITY FOR M3 OVER M2 | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2020-10-01 | — | — | US | disclosed |
| WO-2019110521-A1 | FLUOROPHENYL SUBSTITUTED MUSCARINIC RECEPTOR LIGANDS WITH SELECTIVITY FOR M3 OVER M2 | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2019-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308168-A1 | FLUOROPHENYL SUBSTITUTED MUSCARINIC RECEPTOR LIGANDS WITH SELECTIVITY FOR M3 OVER M2 | CHRM2, CHRM3, CHRM5 | CHRM1 4/4885CHRM3 2/4885ACHE 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.