Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 15/20 | 0.83 |
| ▸ | CHRM1 known ✓ | P11229 | 7/20 | 0.83 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9050182 | 0.85 | CHRM3 (0.68) | CHRM3CHRM2CHRM1 | |
| Iodide SCHEMBL21052162 | 0.84 | CHRM2 (0.61) | CHRM3CHRM2CHRM1CYP2D6CHRM4 | |
| Iodide SCHEMBL4090662 | 0.81 | CHRM2 (0.58) | CHRM3CHRM2CHRM1CYP2D6CHRM4 | |
| Trifluoroacetic Acid SCHEMBL21052199 | 0.81 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CYP2D6CHRM4 | |
| Bromide SCHEMBL9050889 | 0.81 | CHRM3 (0.60) | CHRM3CHRM2CHRM1 | |
| SCHEMBL6231206 | 0.80 | CHRM2 (0.59) | CHRM3CHRM2CHRM1CYP2D6CHRM4 | |
| SCHEMBL13399626 | 0.80 | CHRM2 (0.59) | CHRM3CHRM2CHRM1CYP2D6CHRM4 | |
| Iodide SCHEMBL9048976 | 0.79 | CHRM3 (0.68) | CHRM3 | |
| SCHEMBL231001 | 0.78 | CHRM2 (0.56) | CHRM3CHRM2CHRM1CYP2D6CHRM4 | |
| SCHEMBL231000 | 0.78 | CHRM2 (0.56) | CHRM3CHRM2CHRM1CYP2D6CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747355-A1 | NOVEL CARBAMATE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-12-11 | — | — | EP | disclosed |