Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31210689 | 0.85 | ALOX15 (0.44) | ALOX12ALOX15KDM4EL3MBTL1ERN1 | |
| SCHEMBL5450263 | 0.82 | GAA (0.46) | ALOX12L3MBTL1KMT2AMAPTNPSR1 | |
| SCHEMBL31210947 | 0.78 | ALOX15 (0.47) | ALOX12ALOX15KDM4EERN1KMT2A | |
| SCHEMBL5946203 | 0.77 | HPGD (0.54) | ALOX12ALOX15KMT2AMAPTLMNA | |
| SCHEMBL21055549 | 0.74 | PLK1 (0.58) | ALOX12KDM4EKMT2AMAPTNPC1 | |
| SCHEMBL5946149 | 0.71 | MEN1 (0.52) | KDM4EKMT2AMAPTNPC1RAB9A | |
| SCHEMBL11918917 | 0.71 | ALDH1A1 (0.56) | KDM4EL3MBTL1KMT2AMAPTNPSR1 | |
| SCHEMBL8203312 | 0.70 | CA12 (0.37) | ALOX15KDM4EL3MBTL1KMT2AMAPT | |
| SCHEMBL12235984 | 0.70 | MAPT (0.51) | ALOX12KDM4EKMT2AMAPTLMNA | |
| SCHEMBL29514133 | 0.70 | MAPT (0.51) | ALOX12KDM4EKMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250339406-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2025-11-06 | — | — | US | disclosed |
| US-12364688-B2 | NSD family inhibitors and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2025-07-22 | — | — | US | disclosed |
| US-20230046569-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-02-16 | — | — | US | disclosed |
| US-11324729-B2 | NSD family inhibitors and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-05-10 | — | — | US | disclosed |
| CN-112040947-A | NSD family inhibitors and methods of treatment therewith | 密歇根大学董事会 | 2020-12-04 | — | — | CN | disclosed |
| EP-3720439-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | The Regents Of The University Of Michigan (US) | 2020-10-14 | — | — | EP | disclosed |
| US-20190183865-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-06-20 | — | — | US | disclosed |
| WO-2019113469-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-06-13 | — | — | WO | disclosed |
| WO-2019113469-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12364688-B2 | NSD family inhibitors and methods of treatment therewith | NSD3, NSD2, NSD1 | ALOX12 3522/4885ALOX15 3680/4885KDM4E 2213/4885 |
| US-20230046569-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | ALOX12 3522/4885ALOX15 3680/4885KDM4E 2213/4885 |
| US-20250339406-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | ALOX12 3522/4885ALOX15 3680/4885KDM4E 2213/4885 |
| US-11324729-B2 | NSD family inhibitors and methods of treatment therewith | NSD3, NSD2, NSD1 | ALOX12 3522/4885ALOX15 3680/4885KDM4E 2213/4885 |
| US-20190183865-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | ALOX12 3522/4885ALOX15 3680/4885KDM4E 2213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.