Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aceglumate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 12/20 | 0.42 |
| ▸ | FNTB | P49356 | 12/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 10/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aceglumate SCHEMBL28885877 | 1.00 | FNTA (0.42) | FNTAFNTBPGGT1BFOLH1NOD1 | |
| Aceglumate SCHEMBL28443403 | 1.00 | FNTA (0.42) | FNTAFNTBPGGT1BFOLH1NOD1 | |
| Acetylglutamic Acid SCHEMBL365384 | 1.00 | FNTA (0.42) | FNTAFNTBPGGT1BFOLH1NOD1 | |
| Arginine SCHEMBL4059260 | 0.91 | ALOX15 (0.45) | FNTAFNTBPGGT1BFOLH1NOD1 | |
| Arginine SCHEMBL458502 | 0.91 | ALOX15 (0.45) | FNTAFNTBPGGT1BFOLH1NOD1 | |
| Arginine SCHEMBL6668510 | 0.88 | FOLH1 (0.51) | FOLH1NOD1KMT2A | |
| Arginine SCHEMBL18660568 | 0.87 | ALOX15 (0.49) | FNTAFNTBPGGT1BNOD1ALOX15 | |
| Arginine SCHEMBL6517506 | 0.87 | ALOX15 (0.49) | FNTAFNTBPGGT1BNOD1ALOX15 | |
| Arginine SCHEMBL4052601 | 0.87 | ALOX15 (0.49) | FNTAFNTBPGGT1BNOD1ALOX15 | |
| SCHEMBL30463274 | 0.87 | FOLH1 (0.46) | FNTAFNTBPGGT1BFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3271012-B1 | DEVICES FOR PROVIDING SKIN CARE USING PHOTOTHERAPY | INDERM (FR) | 2019-06-19 | — | — | EP | claimed |