Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 5/20 | 0.35 |
| ▸ | CD38 | P28907 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 2/20 | 0.31 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2105823 | 0.80 | HTT (0.43) | JAK3JAK2JAK1ALDH1A1S1PR1 | |
| SCHEMBL9923111 | 0.70 | TAS1R3 (0.37) | JAK3JAK2JAK1ALDH1A1S1PR1 | |
| SCHEMBL9923308 | 0.67 | TAS1R3 (0.37) | JAK3JAK2JAK1ALDH1A1S1PR1 | |
| SCHEMBL4069377 | 0.67 | JAK3 (0.46) | JAK3JAK2JAK1ALDH1A1S1PR1 | |
| SCHEMBL15946691 | 0.67 | GBA1 (0.38) | JAK3JAK2JAK1ALDH1A1TAS1R3 | |
| SCHEMBL9923421 | 0.66 | TSHR (0.38) | JAK3JAK2JAK1ALDH1A1S1PR1 | |
| SCHEMBL9923408 | 0.66 | TSHR (0.40) | JAK3JAK2JAK1ALDH1A1S1PR1 | |
| SCHEMBL16243176 | 0.66 | INSR (0.39) | JAK2JAK1ALDH1A1 | |
| SCHEMBL9920352 | 0.66 | JAK2 (0.46) | JAK3JAK2JAK1TSHR | |
| SCHEMBL21138781 | 0.65 | CD38 (0.42) | JAK3JAK2JAK1ALDH1A1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163767-B2 | Heterocyclic Janus Kinase 3 inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| EP-2251341-A1 | Heterocyclic Janus kinase 3 inhibitors | Astellas Pharma Inc. (JP) | 2010-11-17 | — | — | EP | disclosed |