Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ATF4 | P18848 | 2/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL21050151 | 1.00 | GLS (0.47) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL21050152 | 1.00 | GLS (0.47) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL24225710 | 0.92 | MEN1 (0.53) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL23920621 | 0.86 | KMT2A (0.58) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL21819474 | 0.85 | MEN1 (0.45) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL21050174 | 0.84 | KMT2A (0.54) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL24225718 | 0.78 | GLS (0.48) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL28522347 | 0.78 | GLS (0.48) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL22614290 | 0.78 | CYP1A2 (0.47) | GLSMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL22614291 | 0.78 | CYP1A2 (0.47) | GLSMEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3723762-A2 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2020-10-21 | — | — | EP | disclosed |
| WO-2019118785-A2 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2019-06-20 | — | — | WO | disclosed |