Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3160335 | 0.84 | HSD17B10 (0.41) | TP53TSHRCA12CA1CA9 | |
| SCHEMBL924527 | 0.81 | HSD17B10 (0.49) | TP53TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL924129 | 0.80 | HSD17B10 (0.51) | ALDH1A1KDM4EHSD17B10HPGDKMT2A | |
| SCHEMBL21098659 | 0.79 | KMT2A (0.36) | KDM2BTP53TSHRCA12CA1 | |
| SCHEMBL21098119 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4KDM2B | |
| SCHEMBL924794 | 0.74 | USP2 (0.40) | ALDH1A1KDM4EHSD17B10MAPTTDP1 | |
| SCHEMBL19585639 | 0.71 | CRBN (0.51) | TSHRALDH1A1DDB1CRBNTDP1 | |
| SCHEMBL30738993 | 0.71 | TDP1 (0.32) | TP53TSHRCA12CA1CA9 | |
| SCHEMBL20812749 | 0.70 | DDB1 (0.35) | CA12CA1CA9CA2DDB1 | |
| SCHEMBL3174187 | 0.66 | IDH1 (0.50) | TP53TSHRCA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118612-A1 | TARGETING COMPOUNDS | ZAFGEN, INC. (US) | 2019-06-20 | — | — | WO | disclosed |
| WO-2019118612-A1 | TARGETING COMPOUNDS | ZAFGEN, INC. (US) | 2019-06-20 | — | — | WO | disclosed |