Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861183 | 0.76 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL21065258 | 0.75 | KMT2A (0.58) | KDM4EHSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL12759656 | 0.73 | HSD17B10 (0.56) | PDE10AKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL24848571 | 0.72 | KDM4E (0.49) | KDM4EHSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL17993463 | 0.71 | KDM4E (0.65) | KDM4EHSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL18057364 | 0.71 | KDM4E (0.60) | KDM4EHSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL12838246 | 0.71 | PDE10A (0.67) | PDE10AKDM4EHSD17B10LMNAMAPT | |
| SCHEMBL24848558 | 0.70 | KDM4E (0.46) | PDE10AKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL11169562 | 0.70 | HSD17B10 (0.52) | PDE10AKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL7398110 | 0.69 | PDE10A (0.63) | PDE10AKDM4EHSD17B10LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399922-B1 | Metal complexes of cyclometallated imidazo(1,2-f) phenanthridine and diimidazo(1,2-A;1',2'-C)quinazoline ligands and isoelectronic and benzannulated analogs therof | UNIVERSAL DISPLAY CORP (US) | 2019-06-26 | — | — | EP | claimed |
| EP-2399922-B1 | Metal complexes of cyclometallated imidazo(1,2-f) phenanthridine and diimidazo(1,2-A;1',2'-C)quinazoline ligands and isoelectronic and benzannulated analogs therof | UNIVERSAL DISPLAY CORP (US) | 2019-06-26 | — | — | EP | disclosed |