Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.37 |
| ▸ | PDE1A | P54750 | 5/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067168 | 0.82 | TGFBR1 (0.40) | TGFBR1CYP3A4CYP2C8HTTPTK2 | |
| SCHEMBL21067122 | 0.82 | TGFBR1 (0.42) | TGFBR1CYP3A4CYP2C8HTTPTK2 | |
| SCHEMBL21067153 | 0.81 | TGFBR1 (0.40) | TGFBR1CYP3A4CYP2C8HTR1AADRA1D | |
| SCHEMBL21067266 | 0.80 | TGFBR1 (0.39) | TGFBR1CYP3A4CYP2C8HTR1AADRA1D | |
| SCHEMBL21067262 | 0.79 | TGFBR1 (0.40) | TGFBR1CYP3A4CYP2C8HTTPTK2 | |
| SCHEMBL21067172 | 0.79 | TGFBR1 (0.40) | TGFBR1CYP3A4CYP2C8HTTPTK2 | |
| SCHEMBL22734376 | 0.78 | IDO1 (0.52) | CYP3A4HTTHTR1AADRA1DADRA1A | |
| SCHEMBL21067211 | 0.78 | MAP4K4 (0.39) | TGFBR1CYP3A4CYP2C8HTR1AADRA1D | |
| SCHEMBL21061229 | 0.78 | SYK (0.46) | TGFBR1CYP3A4CYP2C8HTTPKM | |
| SCHEMBL21067190 | 0.77 | TGFBR1 (0.41) | TGFBR1CYP3A4CYP2C8HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200375950-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2020-12-03 | — | — | US | disclosed |
| US-10766893-B2 | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2020-09-08 | — | — | US | disclosed |
| US-20190194189-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200375950-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | PDE12, PDE3A, PDE5A | TGFBR1 1214/4885CYP3A4 648/4885CYP2C8 1375/4885 |
| US-10766893-B2 | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors | PDE12, PDE3B, PDE5A | TGFBR1 1330/4885CYP3A4 573/4885CYP2C8 1563/4885 |
| US-20190194189-A1 | 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS | PDE12, PDE3B, PDE5A | TGFBR1 1330/4885CYP3A4 573/4885CYP2C8 1563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.