Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22734380 | 0.85 | CYP2C19 (0.53) | HDAC6HDAC3HDAC1HDAC2CYP3A4 | |
| SCHEMBL21067122 | 0.83 | TGFBR1 (0.42) | TGFBR1HDAC6PKMCYP3A4CYP2C8 | |
| SCHEMBL27409993 | 0.82 | HDAC6 (0.40) | SYKTGFBR1HDAC6PKMCYP3A4 | |
| SCHEMBL21067190 | 0.82 | TGFBR1 (0.41) | SYKTGFBR1HDAC6PKMCYP3A4 | |
| SCHEMBL21067231 | 0.82 | KCNH3 (0.39) | SYKTGFBR1HDAC6PKMCYP3A4 | |
| SCHEMBL21067262 | 0.81 | TGFBR1 (0.40) | TGFBR1HDAC6HDAC1CYP3A4CYP2C8 | |
| SCHEMBL21067211 | 0.80 | MAP4K4 (0.39) | TGFBR1HDAC6PKMHDAC3HDAC1 | |
| SCHEMBL22574531 | 0.79 | PDE1A (0.43) | TGFBR1 | |
| SCHEMBL21067139 | 0.78 | TGFBR1 (0.45) | TGFBR1PKMKDRCYP3A4CYP2C8 | |
| SCHEMBL21067165 | 0.78 | CTNNB1 (0.38) | TGFBR1HDAC6PKMCYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3723807-A1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H. Lundbeck A/S (DK) | 2020-10-21 | — | — | EP | disclosed |
| WO-2019115566-A1 | COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES | H. LUNDBECK A/S (DK) | 2019-06-20 | — | — | WO | disclosed |