SCHEMBL21067417

SCHEMBL21067417

O=C(O)[C@H]1CC(=O)N(c2ccccc2O)C1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.71
CASP1 P29466 1/20 0.69
CASP7 P55210 1/20 0.69
ALOX15 P16050 1/20 0.66
CA12 O43570 3/20 0.52
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
CA4 P22748 3/20 0.52
CA6 P23280 3/20 0.52
CA7 P43166 3/20 0.52
CA9 Q16790 3/20 0.52
CA5B Q9Y2D0 3/20 0.52
CA14 Q9ULX7 2/20 0.52
KMT2A Q03164 4/20 0.50
CA3 P07451 2/20 0.50
CA13 Q8N1Q1 2/20 0.50
TSHR P16473 1/20 0.50
GRK2 P25098 1/20 0.50
CTDSP1 Q9GZU7 1/20 0.50
RECQL P46063 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20221488 0.86 MAPT (0.54) MAPTCASP1CASP7ALOX15CA12
SCHEMBL15116716 0.86 MAPT (0.57) MAPTCASP1CASP7ALOX15CA12
SCHEMBL27599117 0.84 MAPT (0.71) MAPTCASP1CASP7ALOX15CA12
SCHEMBL25413636 0.83 MAPT (0.69) MAPTCASP1CASP7ALOX15CA12
SCHEMBL20658870 0.83 MAPT (0.69) MAPTCASP1CASP7ALOX15CA12
SCHEMBL11887760 0.83 MAPT (1.00) MAPTCASP1CASP7ALOX15CA12
SCHEMBL15113830 0.82 ALOX15 (0.56) MAPTCASP1CASP7ALOX15CA12
SCHEMBL2560318 0.82 MAPT (0.68) MAPTCASP1CASP7ALOX15CA12
SCHEMBL2555383 0.81 MAPT (0.66) MAPTCASP1CASP7ALOX15CA12
SCHEMBL20116495 0.80 CA12 (0.66) MAPTCASP1CASP7ALOX15CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-20190192691-A1 REGULATED BIOCIRCUIT SYSTEMS OBSIDIAN THERAPEUTICS, INC. 2019-06-27 US disclosed