Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.71 |
| ▸ | PRMT7 | Q9NVM4 | 3/20 | 0.70 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.70 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.70 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.69 |
| ▸ | PNMT | P11086 | 1/20 | 0.69 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.69 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.68 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.67 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.64 |
| ▸ | SRM | P19623 | 1/20 | 0.64 |
| ▸ | SMS | P52788 | 1/20 | 0.64 |
| ▸ | NADK | O95544 | 1/20 | 0.63 |
| ▸ | AHCY | P23526 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4884765 | 0.90 | DOT1L (0.81) | DOT1LPRMT7PRMT5WDR77DNMT3B | |
| SCHEMBL30216716 | 0.89 | DOT1L (0.83) | DOT1LPRMT7PRMT5WDR77DNMT3B | |
| SCHEMBL6897966 | 0.89 | DOT1L (0.83) | DOT1LPRMT7PRMT5WDR77DNMT3B | |
| SCHEMBL2829515 | 0.87 | DOT1L (0.82) | DOT1LPRMT7PRMT5WDR77DNMT3B | |
| SCHEMBL2829520 | 0.87 | DOT1L (0.82) | DOT1LPRMT7PRMT5WDR77DNMT3B | |
| SCHEMBL13667507 | 0.83 | EHMT1 (0.74) | DOT1LEHMT1NADKAHCY | |
| SCHEMBL28374784 | 0.83 | EHMT1 (0.74) | DOT1LEHMT1NADKAHCY | |
| SCHEMBL998091 | 0.83 | AHCY (0.79) | DOT1LPRMT7PRMT5WDR77DNMT3B | |
| SCHEMBL2115821 | 0.83 | AHCY (0.79) | DOT1LPRMT7PRMT5WDR77DNMT3B | |
| SCHEMBL7610250 | 0.83 | EHMT1 (0.71) | EHMT1NADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11446398-B2 | Regulated biocircuit systems | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |