Sugi Predict

Sugi Predict / Compounds / SCHEMBL21070513

SCHEMBL21070513

SCHEMBL21070513

Brc1ccc2c(c1)[nH]c1ncccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.49
▸ CHEK1 O14757 1/20 0.49
▸ AURKA O14965 1/20 0.46
▸ PARP1 P09874 1/20 0.46
▸ CCNB2 O95067 2/20 0.44
▸ CDK1 P06493 2/20 0.44
▸ CCNB1 P14635 2/20 0.44
▸ GSK3B P49841 2/20 0.44
▸ CDK5 Q00535 2/20 0.44
▸ CDK5R1 Q15078 2/20 0.44
▸ CCNB3 Q8WWL7 2/20 0.44
▸ AXL P30530 1/20 0.43
▸ CHUK O15111 1/20 0.42
▸ ABL1 P00519 1/20 0.41
▸ LCK P06239 1/20 0.41
▸ FYN P06241 1/20 0.41
▸ PIM1 P11309 1/20 0.41
▸ CCNA2 P20248 1/20 0.41
▸ CDK2 P24941 1/20 0.41
▸ FLT4 P35916 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30273970 0.86 CHUK (0.54) MAPTCHEK1AURKAPARP1CCNB2
SCHEMBL674822 0.86 CHUK (0.54) MAPTCHEK1AURKAPARP1CCNB2
SCHEMBL19320105 0.81 CHEK1 (0.43) MAPTCHEK1AURKAPARP1CCNB2
SCHEMBL23319573 0.79 MAPT (0.49) MAPTCHEK1AURKAPARP1CCNB2
SCHEMBL1586081 0.79 MAPT (0.49) MAPTCHEK1AURKAPARP1GSK3B
SCHEMBL2628369 0.79 KIF11 (0.58) MAPTCHEK1AURKAPARP1GSK3B
SCHEMBL1181804 0.79 MAPT (0.49) MAPTCHEK1AURKAPARP1AXL
SCHEMBL9145 0.77 PARP1 (0.60) MAPTCHEK1AURKAPARP1CHUK
SCHEMBL29410201 0.77 PARP1 (0.60) MAPTCHEK1AURKAPARP1CHUK
SCHEMBL29559082 0.77 PARP1 (0.60) MAPTCHEK1AURKAPARP1CHUK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3886904-B1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-04-22 — — EP disclosed
US-20250325673-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-10-23 — — US disclosed
EP-4613773-A2 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-09-10 — — EP disclosed
EP-3731869-B1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-07-23 — — EP disclosed
US-20250163042-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-05-22 — — US disclosed
US-12258341-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2025-03-25 — — US disclosed
US-20250042902-A1 TRICYCLIC CRBN LIGANDS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-02-06 — — US disclosed
US-20250000985-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-01-02 — — US disclosed
US-12168057-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2024-12-17 — — US disclosed
US-20240239777-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-07-18 — — US disclosed
US-20210323952-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2021-10-21 — — US disclosed
EP-3886904-A1 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2021-10-06 — — EP disclosed
CN-113423427-A IRAK degrading agents and uses thereof 凯麦拉医疗公司 2021-09-21 — — CN disclosed
US-11117889-B1 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2021-09-14 — — US disclosed
EP-3817748-A1 TRICYCLIC CRBN LIGANDS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2021-05-12 — — EP disclosed
US-10874743-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2020-12-29 — — US disclosed
CN-112105385-A IRAK degrading agents and uses thereof 凯麦拉医疗公司 2020-12-18 — — CN disclosed
EP-3731869-A1 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2020-11-04 — — EP disclosed
WO-2020113233-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2020-06-04 — — WO disclosed
US-20190192668-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2019-06-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10874743-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-20250325673-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-12258341-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-20250042902-A1 TRICYCLIC CRBN LIGANDS AND USES THEREOF CRBN, CRKL, CUL4A MAPT 1069/4885CHEK1 272/4885AURKA 1417/4885
US-20250163042-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-20250000985-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-11117889-B1 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-20210323952-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-20240239777-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-12168057-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885
US-20190192668-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 MAPT 2459/4885CHEK1 851/4885AURKA 622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.