Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19717898 | 0.87 | APLNR (0.60) | APLNR | |
| SCHEMBL21072989 | 0.87 | APLNR (0.79) | APLNR | |
| SCHEMBL21073253 | 0.84 | APLNR (0.79) | APLNR | |
| SCHEMBL23048510 | 0.82 | APLNR (0.61) | APLNR | |
| SCHEMBL21073787 | 0.82 | APLNR (0.77) | APLNR | |
| SCHEMBL21073517 | 0.81 | APLNR (0.76) | APLNR | |
| SCHEMBL21073165 | 0.80 | APLNR (0.75) | APLNR | |
| SCHEMBL21073323 | 0.79 | APLNR (0.79) | APLNR | |
| SCHEMBL21073842 | 0.79 | APLNR (0.76) | APLNR | |
| SCHEMBL19717878 | 0.78 | APLNR (0.77) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468956-B1 | 6-HYDROXY-5-(PHENYL/HETEROARYLSULFONYL)PYRIMIDIN-4(1H)-ONES AS APJ AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2021-03-03 | — | — | EP | claimed |
| US-20190194173-A1 | 6-HYDROXY-5-(PHENYL/HETEROARYLSULFONYL)PYRIMIDIN-4(1H)-ONE AS APJ AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-27 | — | — | US | disclosed |
| US-20190194173-A1 | 6-HYDROXY-5-(PHENYL/HETEROARYLSULFONYL)PYRIMIDIN-4(1H)-ONE AS APJ AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194173-A1 | 6-HYDROXY-5-(PHENYL/HETEROARYLSULFONYL)PYRIMIDIN-4(1H)-ONE AS APJ AGONISTS | TBXA2R, GPBAR1, CYP2J2 | APLNR 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.