Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | PGK2 | P07205 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12288118 | 0.88 | CES2 (0.50) | CES2GAAMEN1KMT2ACTSL | |
| SCHEMBL2365619 | 0.88 | CES2 (0.50) | CES2GAAMEN1KMT2ACTSL | |
| SCHEMBL17191009 | 0.85 | SMN1; SMN2 (0.42) | CES2GAAMEN1KMT2ACTSL | |
| SCHEMBL16962044 | 0.80 | CES2 (0.45) | CES2CTSLCTSBRAPGEF4GRIN2B | |
| SCHEMBL13954751 | 0.77 | CES2 (0.42) | CES2CTSLCTSBRAPGEF4GRIN2B | |
| SCHEMBL17586584 | 0.77 | CES2 (0.57) | CES2GAARAPGEF4ADCY8ADCY1 | |
| SCHEMBL7786247 | 0.77 | CES2 (0.52) | CES2MEN1KMT2AADCY8ADCY1 | |
| SCHEMBL23526049 | 0.76 | CES2 (0.33) | CES2GAAMEN1KMT2ACTSL | |
| SCHEMBL23526051 | 0.76 | CES2 (0.33) | CES2GAAMEN1KMT2ACTSL | |
| SCHEMBL23526054 | 0.76 | CES2 (0.33) | CES2GAAMEN1KMT2ACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492455-A1 | 1,2,4-TRIAZOLES AS NUCLEAR TRANSPORT MODULATORS AND USE IN THE TREATMENT OF SPECIFIC FORMS OF CANCER | Karyopharm Therapeutics Inc. (US) | 2019-06-05 | — | — | EP | disclosed |