Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.54 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | CHRNG | P07510 | 1/20 | 0.54 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.54 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | CHRND | Q07001 | 1/20 | 0.54 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30930844 | 1.00 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL21074781 | 0.88 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL21074730 | 0.87 | CHRNB4 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL16905604 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1PDGFRBKDRFLT3 | |
| SCHEMBL21074657 | 0.82 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL18309474 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1PDGFRBKDRFLT3 | |
| SCHEMBL22725265 | 0.78 | NPC1 (0.62) | SMN1; SMN2NPC1PDGFRBKDRFLT3 | |
| SCHEMBL19561455 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1PDGFRBKDRFLT3 | |
| SCHEMBL29761231 | 0.76 | CHRNB2 (0.70) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL6886940 | 0.76 | CHRNB2 (0.70) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11084853-B2 | Modified ligand-gated ion channels and methods of use | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2021-08-10 | — | — | US | disclosed |
| US-20210206831-A1 | MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE | HOWARD HUGHES MEDICAL INSTITUTE | 2021-07-08 | — | — | US | disclosed |
| US-10961296-B2 | Modified ligand-gated ion channels and methods of use | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2021-03-30 | — | — | US | disclosed |
| US-20190169264-A1 | MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE | HOWARD HUGHES MEDICAL INSTITUTE | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210206831-A1 | MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE | GRIK4, GRIK2, GRIK5 | CHRNB2 83/4885CHRNA4 64/4885CHRNB4 78/4885 |
| US-11084853-B2 | Modified ligand-gated ion channels and methods of use | GRIK4, GRIK2, GRIK5 | CHRNB2 84/4885CHRNA4 65/4885CHRNB4 81/4885 |
| US-20190169264-A1 | MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE | GRIK4, GRIK2, GRIK5 | CHRNB2 83/4885CHRNA4 64/4885CHRNB4 78/4885 |
| US-10961296-B2 | Modified ligand-gated ion channels and methods of use | GRIK4, GRIK2, GRIK5 | CHRNB2 83/4885CHRNA4 64/4885CHRNB4 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.