Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | YES1 | P07947 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16905604 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2KDRNPC1PDGFRBFLT3 | |
| SCHEMBL21074670 | 0.80 | CHRNB2 (0.54) | SMN1; SMN2KDRNPC1PDGFRBFLT3 | |
| SCHEMBL30930844 | 0.80 | CHRNB2 (0.54) | SMN1; SMN2KDRNPC1PDGFRBFLT3 | |
| SCHEMBL22725265 | 0.78 | NPC1 (0.62) | SMN1; SMN2KDRNPC1PDGFRBFLT3 | |
| SCHEMBL19561455 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2KDRNPC1PDGFRBFLT3 | |
| SCHEMBL6215142 | 0.76 | NPC1 (0.73) | SMN1; SMN2KDRNPC1PDGFRBFLT3 | |
| SCHEMBL23343516 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2KDRNPC1PDGFRBFLT3 | |
| Ag1295 SCHEMBL925674 | 0.73 | NPC1 (1.00) | SMN1; SMN2KDRNPC1PDGFRBFLT3 | |
| SCHEMBL16905564 | 0.73 | CNR2 (0.43) | SMN1; SMN2NPC1RAB9AALOX5APFEN1 | |
| SCHEMBL8499923 | 0.73 | SMN1; SMN2 (0.69) | SMN1; SMN2KDRNPC1PDGFRBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11005050-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-05-11 | — | — | US | disclosed |
| EP-3094638-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-11-08 | — | — | EP | disclosed |
| US-20160365520-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-12-15 | — | — | US | disclosed |
| US-20160365520-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11005050-B2 | Metal complexes | SOD1, AP1M1, AP3M1 | SMN1; SMN2 3736/4885KDR 4513/4885NPC1 3516/4885 |
| US-20160365520-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | SMN1; SMN2 3736/4885KDR 4513/4885NPC1 3516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.