Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17327534 | 0.94 | CHRM2 (0.44) | P2RX7F2KDM4ESMN1; SMN2CHRM2 | |
| SCHEMBL13403369 | 0.88 | MMP2 (0.37) | P2RX7F2CHRM2CHRM4CHRM5 | |
| SCHEMBL12258952 | 0.85 | P2RX7 (0.45) | P2RX7F2KDM4ESMN1; SMN2CHRM2 | |
| SCHEMBL406540 | 0.85 | P2RX7 (0.45) | P2RX7F2KDM4ESMN1; SMN2CHRM2 | |
| SCHEMBL10136486 | 0.85 | P2RX7 (0.45) | P2RX7F2KDM4ESMN1; SMN2CHRM2 | |
| SCHEMBL17069029 | 0.83 | F2 (0.47) | P2RX7F2KDM4ESMN1; SMN2CHRM2 | |
| SCHEMBL2757971 | 0.81 | POLB (0.47) | P2RX7F2KDM4ESMN1; SMN2TNKS | |
| SCHEMBL17069028 | 0.81 | P2RX7 (0.43) | P2RX7F2KDM4ESMN1; SMN2TNKS | |
| SCHEMBL3279377 | 0.80 | P2RX7 (0.51) | P2RX7F2KDM4ESMN1; SMN2TNKS | |
| SCHEMBL13629804 | 0.79 | CHRM2 (0.42) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |