Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075238 | 0.90 | CACNA2D1 (0.53) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL11381417 | 0.83 | OPRM1 (0.58) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL11384842 | 0.82 | OPRM1 (0.59) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL2306320 | 0.81 | L3MBTL3 (0.61) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| Hydrochloric Acid SCHEMBL6984780 | 0.80 | L3MBTL3 (0.59) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL19083885 | 0.79 | CACNA2D1 (0.53) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL17428330 | 0.79 | CACNA2D1 (0.53) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL19075516 | 0.77 | CACNA2D1 (0.51) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL20697765 | 0.77 | CACNA2D1 (0.51) | CHRM2ADRA2ACHRM1DRD1DRD3 | |
| SCHEMBL21075626 | 0.77 | NPSR1 (0.44) | CHRM2ADRA2ACHRM1DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |