SCHEMBL21075978

SCHEMBL21075978

Cc1ccc(C(C)c2ccc3nc(N4CCC4)c(Cc4ccc(C(F)(F)F)cc4)c(Cl)c3c2)c(C)n1

nearest known ligand 0.50

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16632362 0.91 RORC (0.51) RORC
SCHEMBL21538873 0.85 RORC (0.50) RORC
SCHEMBL16632658 0.78 RORC (0.57) RORC
SCHEMBL16632760 0.77 RORC (0.56) RORC
SCHEMBL16632904 0.75 RORC (0.81) RORC
SCHEMBL16460660 0.74 RORC (0.69) RORC
SCHEMBL18856411 0.72 RORC (0.48) RORC
SCHEMBL21574678 0.71 RORC (0.50) RORC
SCHEMBL16475413 0.71 RORC (0.86) RORC
SCHEMBL21574690 0.71 RORC (0.52) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3057949-B1 SECONDARY ALCOHOL QUINOLINYL MODULATORS OF ROR GAMMA T JANSSEN PHARMACEUTICA NV (BE) 2019-06-05 EP disclosed