Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LGMN | Q99538 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21078020 | 0.81 | JAK2 (0.55) | — | |
| SCHEMBL2165481 | 0.76 | ALDH1A1 (0.67) | MAPTHPGDLGMNKMT2AMEN1 | |
| SCHEMBL3436315 | 0.76 | ALDH1A1 (0.64) | MAPTHPGDLGMNKMT2AMEN1 | |
| SCHEMBL196131 | 0.73 | HPGD (0.61) | MAPTHPGDLGMNKMT2AMEN1 | |
| SCHEMBL2080093 | 0.73 | LGMN (0.71) | MAPTHPGDLGMNKMT2AMEN1 | |
| SCHEMBL14804207 | 0.73 | HPGD (0.61) | MAPTHPGDLGMNKMT2AMEN1 | |
| SCHEMBL18914465 | 0.72 | MEN1 (0.65) | MAPTHPGDLGMNKMT2AMEN1 | |
| SCHEMBL18914464 | 0.72 | HPGD (0.60) | MAPTHPGDLGMNKMT2AMEN1 | |
| SCHEMBL3252309 | 0.72 | HPGD (0.84) | MAPTHPGDLGMNKMT2AMEN1 | |
| SCHEMBL31458523 | 0.72 | TSHR (0.60) | MAPTHPGDLGMNKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |