Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56575 | 0.82 | NPC1 (0.57) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL872608 | 0.82 | OPRM1 (0.56) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL432561 | 0.82 | OPRM1 (0.59) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL504355 | 0.81 | OPRM1 (0.70) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL11211164 | 0.81 | OPRM1 (0.61) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL13548727 | 0.81 | OPRM1 (0.66) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL18768887 | 0.80 | NPC1 (0.55) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL19249603 | 0.80 | NPC1 (0.55) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL181145 | 0.80 | NPC1 (0.55) | OPRM1CA12CA1CA2CA9 | |
| SCHEMBL8580359 | 0.80 | CA12 (0.60) | OPRM1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145929-B1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-13 | — | — | EP | disclosed |
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |