Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187550 | 0.80 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBRXFP1MAPT | |
| SCHEMBL6988277 | 0.80 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBRXFP1MAPT | |
| SCHEMBL2993708 | 0.79 | SRD5A2 (0.57) | ALDH1A1KDM4EPOLBRXFP1MAPT | |
| SCHEMBL5187629 | 0.77 | SLC18A3 (0.56) | ALDH1A1KDM4EPOLBRXFP1LMNA | |
| SCHEMBL13874024 | 0.76 | MEN1 (0.66) | ALDH1A1KDM4EPOLBRXFP1MAPT | |
| Hydrochloric Acid SCHEMBL3846012 | 0.75 | MEN1 (0.69) | ALDH1A1KDM4EPOLBRXFP1MAPT | |
| SCHEMBL4771785 | 0.67 | SLC18A3 (0.56) | ALDH1A1KDM4EPOLBRXFP1SLC18A3 | |
| SCHEMBL2989814 | 0.65 | PLK1 (0.44) | ALDH1A1KDM4EPOLBRXFP1MAPT | |
| SCHEMBL21078129 | 0.65 | SLC18A3 (0.45) | ALDH1A1KDM4EPOLBRXFP1MAPT | |
| SCHEMBL29967623 | 0.63 | KMT2A (0.41) | KDM4EMAPTLMNASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |