Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.61 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12122918 | 0.83 | OPRM1 (0.63) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL13876257 | 0.82 | OPRM1 (0.59) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL10819396 | 0.79 | OPRM1 (0.58) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL17465640 | 0.79 | OPRM1 (0.64) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL14899046 | 0.78 | OPRM1 (0.56) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL10821867 | 0.78 | OPRM1 (0.56) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL11683633 | 0.77 | OPRM1 (0.56) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL17220377 | 0.77 | SCD5 (0.57) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL1040389 | 0.76 | OPRM1 (0.54) | OPRM1OPRK1OPRD1OPRL1HSD11B1 | |
| SCHEMBL1040539 | 0.76 | OPRM1 (0.54) | OPRM1OPRK1OPRD1OPRL1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |