Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | HPN | P05981 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26033449 | 0.76 | ALDH1A1 (0.44) | ALDH1A1LMNASLC6A3SLC6A2CES2 | |
| SCHEMBL22415242 | 0.75 | ALDH1A1 (0.45) | L3MBTL1ALDH1A1LMNACYP3A4HSD17B10 | |
| SCHEMBL14099587 | 0.74 | HRH3 (0.39) | ALDH1A1LMNACYP3A4HSD17B10KDM4E | |
| SCHEMBL14233766 | 0.72 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1GAAHPGD | |
| SCHEMBL24673682 | 0.71 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1 | |
| SCHEMBL12302001 | 0.71 | ALDH1A1 (0.48) | ALDH1A1LMNACES2CES1GAA | |
| SCHEMBL10455765 | 0.70 | EGFR (0.62) | L3MBTL1ALDH1A1LMNAGAAHPGD | |
| SCHEMBL23030546 | 0.70 | CNR2 (0.40) | HPGD | |
| SCHEMBL9102795 | 0.70 | HRH3 (0.40) | LMNASLC6A3SLC6A2OPRM1OPRD1 | |
| SCHEMBL12964103 | 0.69 | CHRM2 (0.50) | L3MBTL1ALDH1A1LMNASLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |