Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13103451 | 0.85 | SMN1; SMN2 (0.51) | LMNAJAK2JAK1GAACCNC | |
| SCHEMBL27292690 | 0.79 | SMN1; SMN2 (0.54) | LMNAHSD17B10NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16565645 | 0.78 | THRB (0.44) | THRBJAK2JAK1GAAALOX15 | |
| SCHEMBL24528818 | 0.77 | ALPI (0.41) | LMNACCNCCDK8SMN1; SMN2ALDH1A1 | |
| SCHEMBL17382013 | 0.76 | ALPI (0.47) | LMNACCNCCDK8SMN1; SMN2 | |
| SCHEMBL12121175 | 0.76 | ALPI (0.47) | LMNACCNCCDK8HSD17B10SMN1; SMN2 | |
| SCHEMBL19226570 | 0.76 | P2RY12 (0.41) | LMNAJAK2JAK1GAASMN1; SMN2 | |
| SCHEMBL19014559 | 0.73 | CCNC (0.51) | LMNAGAACCNCCDK8SMN1; SMN2 | |
| SCHEMBL18909230 | 0.73 | THRB (0.53) | THRBLMNAGAAALOX15TSHR | |
| SCHEMBL13102474 | 0.72 | POLB (0.50) | LMNACCNCCDK8SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |