Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27292690 | 0.86 | SMN1; SMN2 (0.54) | ALPIALPGPLAASMN1; SMN2ALDH1A1 | |
| SCHEMBL17382013 | 0.83 | ALPI (0.47) | ALPIALPGPLAASMN1; SMN2CCNC | |
| SCHEMBL12121175 | 0.83 | ALPI (0.47) | ALPIALPGPLAASMN1; SMN2ALDH1A1 | |
| SCHEMBL19226570 | 0.83 | P2RY12 (0.41) | ALPIALPGPLAASMN1; SMN2ALDH1A1 | |
| SCHEMBL17340938 | 0.81 | ALPI (0.37) | ALPIALPGPLAASMN1; SMN2ALDH1A1 | |
| SCHEMBL19014559 | 0.80 | CCNC (0.51) | ALPIALPGPLAASMN1; SMN2ALDH1A1 | |
| SCHEMBL24528819 | 0.80 | LMNA (0.39) | ALPIALPGPLAASMN1; SMN2ALDH1A1 | |
| SCHEMBL13102474 | 0.79 | POLB (0.50) | ALPIALPGPLAASMN1; SMN2ALDH1A1 | |
| SCHEMBL13103451 | 0.79 | SMN1; SMN2 (0.51) | ALPIALPGPLAASMN1; SMN2ALDH1A1 | |
| SCHEMBL21078192 | 0.77 | THRB (0.52) | SMN1; SMN2ALDH1A1CCNCCDK8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023242598-A1 | BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2023-12-21 | — | — | WO | disclosed |
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |