Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | DNM2 | P50570 | 1/20 | 0.31 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16565934 | 0.70 | CHRM2 (0.36) | — | |
| SCHEMBL17888440 | 0.69 | CHRNB4 (0.46) | — | |
| Hydrochloric Acid SCHEMBL16795310 | 0.68 | HRH4 (0.44) | — | |
| SCHEMBL3912567 | 0.68 | TSHR (0.46) | — | |
| SCHEMBL17886849 | 0.67 | JAK1 (0.35) | JAK1 | |
| Dimethylamine SCHEMBL9636536 | 0.62 | TSHR (0.41) | — | |
| SCHEMBL24375875 | 0.60 | NOS3 (0.40) | — | |
| SCHEMBL21573355 | 0.60 | TAS1R3 (0.36) | GSK3AGSK3BJAK2JAK1TYK2 | |
| SCHEMBL22606895 | 0.59 | PSMB5 (0.32) | PSMB5 | |
| SCHEMBL14851141 | 0.59 | NOS3 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |