Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDKN1A | P38936 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.41 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107990 | 0.89 | CDKN1A (0.55) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| Lorediplon SCHEMBL29376531 | 0.88 | CDKN1A (0.54) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| Lorediplon SCHEMBL1316601 | 0.88 | CDKN1A (0.54) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| SCHEMBL3241433 | 0.88 | CDKN1A (0.54) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| SCHEMBL5814165 | 0.85 | CDKN1A (0.56) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| Indiplon SCHEMBL75094 | 0.83 | CDKN1A (0.61) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| Indiplon SCHEMBL30292630 | 0.83 | CDKN1A (0.61) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| Indiplon SCHEMBL3714581 | 0.83 | CDKN1A (0.61) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| Indiplon SCHEMBL4807177 | 0.82 | CDKN1A (0.60) | CDKN1AKDM4EALDH1A1PIM1MAPK13 | |
| SCHEMBL2105416 | 0.81 | CDKN1A (0.45) | CDKN1AKDM4EALDH1A1PIM1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158632-B2 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions | FERRER INTERNACIONAL, S.A. (ES) | 2012-04-17 | — | — | US | claimed |
| EP-2059521-B1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | FERRER INT (ES) | 2010-06-02 | — | — | EP | claimed |
| US-20090264448-A1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | FERRER INTERNATIONAL, S.A. (ES) | 2009-10-22 | — | — | US | claimed |
| EP-1884516-A1 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions | FERRER INTERNACIONAL, S.A. (ES) | 2008-02-06 | — | — | EP | claimed |
| US-8158632-B2 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions | FERRER INTERNACIONAL, S.A. (ES) | 2012-04-17 | — | — | US | disclosed |
| EP-2059521-B1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | FERRER INT (ES) | 2010-06-02 | — | — | EP | disclosed |
| US-20090264448-A1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | FERRER INTERNATIONAL, S.A. (ES) | 2009-10-22 | — | — | US | disclosed |
| EP-1884516-A1 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions | FERRER INTERNACIONAL, S.A. (ES) | 2008-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264448-A1 | PYRAZOLO[1,5-A]PYRIMIDINES, PROCESSES, USES AND COMPOSITIONS | P2RX5, GABRA5, P2RX1 | CDKN1A 1497/4885KDM4E 740/4885ALDH1A1 1005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.