Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | VDR | P11473 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23502011 | 0.86 | KIF11 (0.53) | MEN1KMT2AKIF11KDM4EVDR | |
| SCHEMBL22167595 | 0.81 | KIF11 (0.53) | KIF11VDR | |
| SCHEMBL24576377 | 0.79 | TP53 (0.42) | MEN1KMT2AKIF11VDR | |
| SCHEMBL19481419 | 0.77 | AHR (0.52) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL29507671 | 0.76 | KIF11 (0.61) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL1517851 | 0.76 | KIF11 (0.61) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL18949683 | 0.76 | KIF11 (0.49) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL5262289 | 0.75 | MEN1 (0.43) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL5199528 | 0.74 | CCNB2 (0.50) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL8997990 | 0.73 | VDR (0.67) | MEN1KMT2AKIF11CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10633386-B2 | BET protein degraders | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190169195-A1 | BET PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633386-B2 | BET protein degraders | BRD4, BET1, BRD1 | MEN1 1616/4885KMT2A 279/4885KIF11 1059/4885 |
| US-20190169195-A1 | BET PROTEIN DEGRADERS | BRD4, BET1, BRD1 | MEN1 1749/4885KMT2A 315/4885KIF11 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.