Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650033 | 0.88 | NPC1 (0.47) | NPC1RAB9AHSP90AA1S1PR2S1PR4 | |
| SCHEMBL2109052 | 0.83 | NPC1 (0.58) | NPC1RAB9AHSP90AA1S1PR2S1PR4 | |
| Hydrochloric Acid SCHEMBL2112821 | 0.82 | NPC1 (0.57) | NPC1RAB9AHSP90AA1S1PR2S1PR4 | |
| SCHEMBL5096659 | 0.66 | NPC1 (0.66) | NPC1RAB9AHSP90AA1ADAMTS5KMT2A | |
| SCHEMBL2109899 | 0.65 | HSP90AA1 (0.56) | NPC1RAB9AHSP90AA1ADAMTS5KMT2A | |
| SCHEMBL4045007 | 0.65 | NPC1 (0.78) | NPC1RAB9AHSP90AA1KMT2AMEN1 | |
| SCHEMBL17530039 | 0.64 | S1PR2 (0.58) | NPC1RAB9AHSP90AA1S1PR2S1PR4 | |
| SCHEMBL17530040 | 0.64 | S1PR2 (0.58) | NPC1RAB9AHSP90AA1S1PR2S1PR4 | |
| SCHEMBL1811300 | 0.64 | NPC1 (1.00) | NPC1RAB9AHSP90AA1ADAMTS5KMT2A | |
| SCHEMBL29856009 | 0.64 | KMT2A (0.64) | NPC1RAB9AHSP90AA1ADAMTS5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158799-B2 | Hydroxyquinoline derivatives | Merck Patent Gesellschaft MIT Meschraenkter Haftung (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312278-A1 | Hydroxyquinoline Derivatives | MKI67, CCNT1, CCNY | NPC1 1502/4885RAB9A 2373/4885HSP90AA1 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.