Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | HTT | P42858 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30876685 | 0.92 | KMT2A (0.57) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL29855987 | 0.86 | NPC1 (0.82) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL4039606 | 0.86 | NPC1 (0.82) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL4040420 | 0.85 | NPC1 (0.80) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL24634614 | 0.84 | HTT (0.68) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL30876598 | 0.84 | HTT (0.68) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL29856092 | 0.84 | KMT2A (0.51) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL29856155 | 0.84 | HTT (0.54) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL27196452 | 0.84 | HTT (0.54) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 | |
| SCHEMBL24634711 | 0.84 | HTT (0.62) | KMT2AHTTSMN1; SMN2MEN1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124419-A1 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-04-18 | — | — | US | disclosed |
| EP-4288416-A2 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | The Regents Of The University Of Michigan (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169834-A2 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124419-A1 | SMALL MOLECULE INHIBITORS OF GRP78 AND USES THEREOF | HSPA5, HSPA2, PSMG3 | KMT2A 4365/4885HTT 2113/4885SMN1; SMN2 2825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.