Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12873406 | 0.86 | CYP1A2 (0.47) | TGFBR1CYP1A2KDM4EMEN1KMT2A | |
| SCHEMBL21084058 | 0.85 | TGFBR1 (0.60) | TGFBR1TGFBR2 | |
| SCHEMBL19657302 | 0.82 | TGFBR1 (0.47) | TGFBR1CYP1A2PRMT5WDR77FYN | |
| SCHEMBL19840418 | 0.80 | GAA (0.45) | TGFBR1CYP1A2KDM4EMEN1KMT2A | |
| SCHEMBL12850753 | 0.79 | TNF (0.51) | TGFBR1KDM4EPRMT5WDR77SMN1; SMN2 | |
| SCHEMBL23872989 | 0.79 | GRN (0.45) | TGFBR1KDM4ENPC1FYNTGFBR2 | |
| SCHEMBL18208326 | 0.79 | DYRK1A (0.50) | TGFBR1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL21083366 | 0.75 | TGFBR1 (0.80) | TGFBR1TGFBR2 | |
| SCHEMBL17437976 | 0.74 | TYK2 (0.54) | TGFBR1KDM4EHPGDHSD17B10FYN | |
| SCHEMBL18654622 | 0.74 | TGFBR1 (0.43) | TGFBR1KDM4ENPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492461-A1 | NITROGENOUS HETEROCYCLIC AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF | Shanghai Yingli Pharmaceutical Co. Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |