Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 12/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15254975 | 0.83 | TNF (0.47) | TGFBR1CLK1FYNCREBBP | |
| SCHEMBL12873406 | 0.82 | CYP1A2 (0.47) | TGFBR1FYNPRMT5WDR77CYP1A2 | |
| SCHEMBL21083379 | 0.82 | TGFBR1 (0.52) | TGFBR1FYNPRMT5WDR77CYP1A2 | |
| SCHEMBL21084058 | 0.81 | TGFBR1 (0.60) | TGFBR1 | |
| SCHEMBL21024065 | 0.81 | TGFBR1 (0.44) | TGFBR1CLK1FYNCREBBP | |
| SCHEMBL21765953 | 0.77 | IRAK4 (0.50) | TGFBR1CLK1CREBBP | |
| SCHEMBL19578150 | 0.76 | GBA1 (0.48) | CLK1 | |
| SCHEMBL22891212 | 0.76 | HSD11B1 (0.51) | TGFBR1CLK1 | |
| SCHEMBL19840418 | 0.76 | GAA (0.45) | TGFBR1CYP1A2 | |
| SCHEMBL19467090 | 0.72 | NPSR1 (0.54) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |