Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21084195 | 0.87 | TGFBR1 (0.61) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL22955513 | 0.86 | TGFBR1 (0.60) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL24654175 | 0.86 | TGFBR1 (0.60) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL21084232 | 0.80 | TGFBR1 (1.00) | TGFBR1 | |
| SCHEMBL16917273 | 0.80 | TGFBR1 (0.62) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL22955994 | 0.80 | TGFBR1 (1.00) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL22955787 | 0.80 | TGFBR1 (0.67) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL21084064 | 0.77 | TGFBR1 (0.63) | TGFBR1ALDH1A1 | |
| SCHEMBL30117458 | 0.76 | TGFBR1 (0.64) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL15638831 | 0.76 | TGFBR1 (0.64) | TGFBR1PIK3CDPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492461-A1 | NITROGENOUS HETEROCYCLIC AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF | Shanghai Yingli Pharmaceutical Co. Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |