Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25846106 | 0.98 | ALOX5 (0.44) | ALOX5PTGS1PTGS2MTNR1AMTNR1B | |
| SCHEMBL24101747 | 0.84 | MCHR1 (0.46) | KDM4EALDH1A1HTR6MCHR1 | |
| SCHEMBL24101466 | 0.83 | HTR2A (0.51) | KDM4EHSD17B10MAPK1MCHR1 | |
| SCHEMBL12205195 | 0.82 | ALOX5 (0.41) | ALOX5PTGS1PTGS2MTNR1AMTNR1B | |
| SCHEMBL12127529 | 0.82 | MTNR1A (0.43) | ALOX5PTGS1PTGS2MTNR1AMTNR1B | |
| SCHEMBL12288143 | 0.82 | ALOX5 (0.41) | ALOX5PTGS1PTGS2MTNR1AMTNR1B | |
| SCHEMBL12927934 | 0.81 | ALOX5 (0.43) | ALOX5PTGS1PTGS2MTNR1AMTNR1B | |
| SCHEMBL25846111 | 0.79 | MCHR1 (0.52) | HTR6KCNH2MCHR1 | |
| SCHEMBL12127535 | 0.79 | MTNR1A (0.40) | ALOX5PTGS1PTGS2MTNR1AMTNR1B | |
| SCHEMBL12225029 | 0.77 | MTNR1A (0.40) | ALOX5PTGS1PTGS2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |