Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.49 |
| ▸ | HTR1D | P28221 | 11/20 | 0.48 |
| ▸ | HTR1F | P30939 | 11/20 | 0.48 |
| ▸ | HTR1B | P28222 | 10/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12127442 | 0.82 | OPRL1 (0.43) | APP | |
| SCHEMBL12132005 | 0.81 | APP (0.56) | APPHTR1F | |
| SCHEMBL12127691 | 0.79 | JAK1 (0.49) | — | |
| SCHEMBL25787927 | 0.76 | OPRL1 (0.65) | — | |
| SCHEMBL12285936 | 0.74 | APP (0.74) | APPHTR1DHTR1FHTR1BCYP1A2 | |
| SCHEMBL12127453 | 0.74 | OPRM1 (0.44) | APPHTR1DHTR1FHTR1BCYP1A2 | |
| SCHEMBL12874679 | 0.74 | DHCR7 (0.51) | — | |
| SCHEMBL21088140 | 0.73 | APP (0.63) | APPHTR1DHTR1FHTR1BCYP1A2 | |
| SCHEMBL21089220 | 0.73 | APP (0.75) | APPHTR1DHTR1FHTR1BCYP1A2 | |
| SCHEMBL21089219 | 0.71 | APP (0.54) | APPHTR1DHTR1FHTR1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |