Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 11/20 | 0.53 |
| ▸ | RAB9A | P51151 | 11/20 | 0.53 |
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14017499 | 0.72 | TGM2 (0.49) | NPC1RAB9AMAPTHTTKDM4E | |
| SCHEMBL1742667 | 0.72 | CYP1A2 (0.81) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL20456546 | 0.72 | SMN1; SMN2 (0.68) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL13412009 | 0.71 | POLB (0.76) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL19412850 | 0.71 | MAPT (0.49) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL6993043 | 0.69 | NPC1 (0.74) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL23114258 | 0.69 | POLB (0.59) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL107421 | 0.69 | RAB9A (1.00) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL179084 | 0.69 | NPC1 (0.79) | SMN1; SMN2TP53NPC1RAB9AMAPT | |
| SCHEMBL179080 | 0.68 | SMN1; SMN2 (0.72) | SMN1; SMN2TP53NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |