Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.64 |
| ▸ | FEN1 | P39748 | 2/20 | 0.64 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.50 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.50 |
| ▸ | TDP2 | O95551 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15916977 | 0.78 | ALOX5AP (1.00) | ALOX5APFEN1 | |
| SCHEMBL24884440 | 0.76 | GRIA1 (0.69) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL15923984 | 0.74 | ALOX5AP (0.72) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL20627386 | 0.73 | ALOX5AP (0.36) | ALOX5APFEN1 | |
| SCHEMBL21089445 | 0.73 | ALOX5AP (0.65) | ALOX5APFEN1 | |
| SCHEMBL10711255 | 0.72 | GRIA1 (0.68) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL21089172 | 0.72 | ALOX5AP (0.60) | ALOX5APFEN1 | |
| SCHEMBL20627332 | 0.72 | FEN1 (0.60) | ALOX5APFEN1 | |
| SCHEMBL1899295 | 0.72 | TDP2 (0.74) | ALOX5APFEN1GRIA1CACNG8TDP2 | |
| SCHEMBL30191144 | 0.72 | TDP2 (0.74) | ALOX5APFEN1GRIA1CACNG8TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495359-A1 | FLAP MODULATORS | Janssen Pharmaceutica NV (BE) | 2019-06-12 | — | — | EP | disclosed |